Methamphetamine 1 is a widely abused and highly addictive stimulant drug. The illicit synthesis of this compound has been achieved most commonly by the reductive amination of phenyl-2-propanone 2, by the Leuckart formamidation of 2 followed by hydrolysis or by the reduction of ephedrine or pseudoephedrine 3 with hydriodic acid and red phosphorus. This latter method is currently the most common encountered in clandestine laboratories in Victoria3. In this investigation, we have studied the structures of the impurities generated along with methamphetamine using this route from pseudoephedrine.
脱氧麻黄碱（甲基苯丙胺，俗称冰毒）是一种被广泛滥用并且极易上瘾的中枢兴奋剂。此化合物非法合成的方法有，通过1-苯基-2丙酮的还原胺化作用；通过1-苯基-2丙酮的洛卡特氐反应后进行水解生成；在红磷、氢碘酸的参与下，通过还原麻黄素或伪麻黄素合成。后一种方法是目前在维多利亚秘密实验室中最为常见的。在实验中我们还研究了通过伪麻黄素这条路径合成脱氧麻黄碱的同时所产生的杂质的结构。